![1-[1-(1-甲基环辛基)-4-哌啶基]-2-[(3R)-3-哌啶基]-1H-苯并咪唑](https://stcdn.activebiopharma.com/active/ABP000953.png)
1028969-49-4
编号ABP000953
化学名称1-[1-(1-甲基环辛基)-4-哌啶基]-2-[(3R)-3-哌啶基]-1H-苯并咪唑
英文名称 MCOPPB trihydrochloride/
MDL: MFCD18251547
分子式C26H40N4
分子量408.63
纯度 >99%
化学名称 : 1-[1-(1-甲基环辛基)-4-哌啶基]-2-[(3R)-3-哌啶基]-1H-苯并咪唑
CAS : 1028969-49-4
英文名称: MCOPPB trihydrochloride/
英文同义词: MCOPPB
溶解度:Unknown
储存条件:at -20℃ 2 years
生物活性
MK-1775 is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM. [1]
It abolishes cyclin-dependent kinase 1 (CDC2) activity by phosphorylation of the Tyr15 residue. It abrogates a DNA damage checkpoint (G2-phase), leading to apoptosis in combination with several DNA-damaging agents selectively in p53-deficient tumor cell lines. It is under clinical trial for advanced solid tumors. [2]
参考文献
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3,4-噻吩二羧酸
4282-29-5
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(S)-4-(2-羟乙基)-2,2-二甲基-1,3-二氧戊环
32233-43-5
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Alfuzosin/
81403-68-1
-
2-氯-4-三氟甲基-1,3-噻唑-5-羧酸乙酯
72850-52-3
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