Home / Products / Others / 1028969-49-4
MCOPPB trihydrochloride/


Cat.No.ABP000953 Chemical NameMCOPPB trihydrochloride/ MDL: MFCD18251547 MolFormulaC26H40N4 MolWeight408.63 Purity >99%

Chemical Name : MCOPPB trihydrochloride/

CAS : 1028969-49-4

Synonyms: MCOPPB

Storage:at -20℃ 2 years


MK-1775 is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM. [1]
It abolishes cyclin-dependent kinase 1 (CDC2) activity by phosphorylation of the Tyr15 residue. It abrogates a DNA damage checkpoint (G2-phase), leading to apoptosis in combination with several DNA-damaging agents selectively in p53-deficient tumor cell lines. It is under clinical trial for advanced solid tumors. [2]


[1] Dai Y et al. Clin Cancer Res. 2010 Jan 15;16(2):376-83