Chemical Name : MCOPPB trihydrochloride/
CAS : 1028969-49-4
Storage:at -20℃ 2 years
MK-1775 is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM. 
It abolishes cyclin-dependent kinase 1 (CDC2) activity by phosphorylation of the Tyr15 residue. It abrogates a DNA damage checkpoint (G2-phase), leading to apoptosis in combination with several DNA-damaging agents selectively in p53-deficient tumor cell lines. It is under clinical trial for advanced solid tumors.