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Biologieal

MK-1775 is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM. ^[1]
It abolishes cyclin-dependent kinase 1 (CDC2) activity by phosphorylation of the Tyr15 residue. It abrogates a DNA damage checkpoint (G2-phase), leading to apoptosis in combination with several DNA-damaging agents selectively in p53-deficient tumor cell lines. It is under clinical trial for advanced solid tumors. ^[2]

Reference

[1] Dai Y et al. Clin Cancer Res. 2010 Jan 15;16(2):376-83