SB939
Cat.No.ABP000582
Chemical NameSB939
CAS929016-96-6
MDL: MFCD17215206
MolFormulaC20H30N4O2
MolWeight358.483
Purity >99%
Chemical Name : SB939
CAS : 929016-96-6
Synonyms: (2E)-3-(2-Butyl-1-[2-(diethylamino)ethyl]-1h-1,3-benzodiazol-5-yl)-n-hydroxyprop-2-enamide
Solubility:DMSO to 100 mM
Storage:at -20
Biologieal
Potent and oral inhibitor of histone deacetylase (HDAC), selective for class I, II and IV HDACs. SB939 shows significant antiproliferative activity against a wide variety of tumor cell lines, with high tumor exposure and efficacy in mouse models of colorectal cancer.Reference
V Novotny-Diermary et al. SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. Mol. Cancer Ther. 2010, 9(3), 642-652-
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