PKI587/PF-05212384,PKI-587

溶解度:DMSO

储存条件:-20C,two years

生物活性

PF-05212384 (PKI-587) is a potent and selective dual PI3K/mTOR inhibitor in clinical trials.it has
shown excellent activity in vitro and in vivo, with antitumor efficacy in both subcutaneous and orthotopic
xenograft tumor models when administered intravenously

参考文献

1. Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5'-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound 26 (PKI-587), a Highly Efficacious Dual Inhibitor