PKI587/PF-05212384,PKI-587

Solubility:DMSO

Storage:-20C,two years

Biologieal

PF-05212384 (PKI-587) is a potent and selective dual PI3K/mTOR inhibitor in clinical trials.it has
shown excellent activity in vitro and in vivo, with antitumor efficacy in both subcutaneous and orthotopic
xenograft tumor models when administered intravenously

Reference

1. Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5'-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound 26 (PKI-587), a Highly Efficacious Dual Inhibitor