D-87503/D87503

溶解度:DMSO

储存条件:-20c two years

生物活性

D-87503, shows an IC50 value of 760nM for Erk2 and 62nM for PI3K respectively.potent inhibitors of the target downstream substrates Akt and Rsk1 in cellular assays. as for example BxPC3 (pancreas carcinoma), Hct116 (colon carcinoma), MDA-MB 468 and 231 (breast carcinoma) was tested with an average EC50 value of 5µM. Mode-of-action studies revealed that the pyridopyrazine-ureas are ATP competitive PI3K and Erk1/2 inhibitors

参考文献

1. Preparation of pyridopyrazines as kinase modulators 2.Novel pyridopyrazine-urea derivatives are highly selective dual mechanism inhibitors of PI3K and Erk1/2