D-106669
D-106669
Cat.No.ABP000091
Chemical NameD-106669
CAS938444-93-0
MolFormulaC17H18N6O
MolWeight322.3644
Purity >98%
Chemical Name : D-106669
CAS : 938444-93-0
Synonyms: 1-ethyl-3-(3-(p-tolylamino)pyrido[2,3-b]pyrazin-6-yl)urea
Solubility:DMSO
Storage:-20c two years
Biologieal
D-106669 has been disclosed with a submicromolar inhibition of PI3Ka.Its pyridopyrazine core,substituted by an anilino residue,has been the base scaffold of a more advanced derivative AEZS-126.this molecule is described as selectitively inhibiting class I PI3K and showed some activity in A549(lung cancer)xenografts mouse model at oral dose of 30mg/kg twice dailyReference
Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway-
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PI3Kalpha inhibitor 1
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BEZ235/NVP-BEZ235/BE-Z235/
915019-65-7
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