D-106669
D-106669
编号ABP000091
化学名称D-106669
CAS938444-93-0
分子式C17H18N6O
分子量322.3644
纯度 >98%
化学名称 : D-106669
CAS : 938444-93-0
英文名称: D-106669
英文同义词: 1-ethyl-3-(3-(p-tolylamino)pyrido[2,3-b]pyrazin-6-yl)urea
溶解度:DMSO
储存条件:-20c two years
生物活性
D-106669 has been disclosed with a submicromolar inhibition of PI3Ka.Its pyridopyrazine core,substituted by an anilino residue,has been the base scaffold of a more advanced derivative AEZS-126.this molecule is described as selectitively inhibiting class I PI3K and showed some activity in A549(lung cancer)xenografts mouse model at oral dose of 30mg/kg twice daily参考文献
Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway-
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