WAY-100635 maleate salt/


Cat.No.ABP000343 Chemical NameWAY-100635 maleate salt/ MDL: MFCD01321056 MolFormulaC25H34N4O2.C4H4O4 MolWeight538.641 Purity >98.5%

Chemical Name : WAY-100635 maleate salt/

CAS : 634908-75-1

Synonyms: N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinylcyclohexanecarboxamide maleate salt;WAY-100635 MALEATE SALT

Solubility:Soluble to 25 mM in water and to 100 mM in DMSO

Storage:at -20℃ 2 years


Potent, silent antagonist of 5-HT1A receptors (IC50 = 2.2 nM; Ki = 0.84 nM for rat 5-HT1A receptors). Displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes.


Zhuang et al (1994) Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2''-pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand. J.Med.Chem. 37 1406. PMID: 8182697. Forster et al (1995) A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Eur.J.Pharmacol. 281 81. PMID: 8566121. Mensonides-Harsema et al (2000) Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635. J.Med.Chem. 43 432. PMID: 10669570.