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Cat.No.ABP000841 Chemical NameJNJ7706621/JNJ-7706621 MDL: MFCD11100270 MolFormulaC15H12F2N6O3S MolWeight394.361 Purity >99.5%

Chemical Name : JNJ7706621/JNJ-7706621

CAS : 443797-96-4

Synonyms: JNJ-7706621

Storage:-20C 2 years


MK-8245, a liver-targeted SCD inhibitor
believed to inhibit the SCD enzyme solely in the liver and not in other tissues for the
following reasons. When SCD inhibition has been measured by desaturation index in
tissues of rodents treated with MK-8245, the desaturation index was significantly
reduced in liver but not in other tissues such as skin, eye and adipose tissue (7). This
inhibition of desaturation index is a direct measure of SCD inhibition


Plasma-based Approach to Measure Target Engagement for Livertargeting