443797-96-4
![4-[[5-氨基-1-(2,6-二氟苯甲酰基)-1H-1,2,4-三唑-3-基]氨基]苯磺酰胺](http://stcdn.activebiopharma.com/active/ABP000841.png)
443797-96-4
编号ABP000841
化学名称4-[[5-氨基-1-(2,6-二氟苯甲酰基)-1H-1,2,4-三唑-3-基]氨基]苯磺酰胺
英文名称 JNJ7706621/JNJ-7706621
MDL: MFCD11100270
分子式C15H12F2N6O3S
分子量394.361
纯度 >99.5%
化学名称 : 4-[[5-氨基-1-(2,6-二氟苯甲酰基)-1H-1,2,4-三唑-3-基]氨基]苯磺酰胺
CAS : 443797-96-4
英文名称: JNJ7706621/JNJ-7706621
英文同义词: JNJ-7706621
储存条件:-20C 2 years
生物活性
MK-8245, a liver-targeted SCD inhibitor
believed to inhibit the SCD enzyme solely in the liver and not in other tissues for the
following reasons. When SCD inhibition has been measured by desaturation index in
tissues of rodents treated with MK-8245, the desaturation index was significantly
reduced in liver but not in other tissues such as skin, eye and adipose tissue (7). This
inhibition of desaturation index is a direct measure of SCD inhibition
参考文献
Plasma-based Approach to Measure Target Engagement for Livertargeting
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CDK8-IN-1
-
WP1130
856243-80-6
-
![N-[5-[(5-叔丁基-1,3-恶唑-2-基)甲硫基]-1,3-噻唑-2-基]哌啶-4-甲酰胺](http://stcdn.activebiopharma.com/active/ABP000845.png)
N-[5-[(5-叔丁基-1,3-恶唑-2-基)甲硫基]-1,3-噻唑-2-基]哌啶-4-甲酰胺
345627-80-7
-
Cdk2 Inhibitor II
222035-13-4
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