1-[1-(1-甲基环辛基)-4-哌啶基]-2-[(3R)-3-哌啶基]-1H-苯并咪唑

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

MK-1775 is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM. ^[1]
It abolishes cyclin-dependent kinase 1 (CDC2) activity by phosphorylation of the Tyr15 residue. It abrogates a DNA damage checkpoint (G2-phase), leading to apoptosis in combination with several DNA-damaging agents selectively in p53-deficient tumor cell lines. It is under clinical trial for advanced solid tumors. ^[2]

参考文献

[1] Dai Y et al. Clin Cancer Res. 2010 Jan 15;16(2):376-83