JNJ7706621/JNJ-7706621

Storage:-20C 2 years

Biologieal

MK-8245, a liver-targeted SCD inhibitor
believed to inhibit the SCD enzyme solely in the liver and not in other tissues for the
following reasons. When SCD inhibition has been measured by desaturation index in
tissues of rodents treated with MK-8245, the desaturation index was significantly
reduced in liver but not in other tissues such as skin, eye and adipose tissue (7). This
inhibition of desaturation index is a direct measure of SCD inhibition

Reference

Plasma-based Approach to Measure Target Engagement for Livertargeting