BIIB021/CNF2024

溶解度:Soluble in DMSO at 10 mM

储存条件:Storage at -20C 2 years

生物活性

 NVP-AUY922 inhibited HSP90α and HSP90β with similar IC₅₀ (median inhibition concentration) values of 13 and 21 nM [23,26], respectively

参考文献

1. 4,5-Diarylisoxazole Hsp90 chaperone inhibitors: Potential therapeutic agents for the treatment of cancer. Brough, P.A., Aherne, W., Barril, et al. 2008, Journal of Medicinal Chemistry 51 (2), pp. 196-218

2. NVP-AUY922: A novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Eccles, S.A., Massey, A., Raynaud, et al. 2008, Cancer Research 68 (8), pp. 2850-2860

3. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Sharp SY, Clarke PA, Powers M, et al. Mol Cancer Ther 2007;6: 1198�C211.