4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide

溶解度:DMSO

储存条件:-20C 2 years

生物活性

An orally bioavailable pan-HER tyrosine kinase inhibitor with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors.

参考文献

1��HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924. Haluska P et al. Mol Cancer Ther. 2008 Sep;7(9):2589-98. Epub 2008 Sep

2. 2��Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Wong TW,et al. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.