Saquinavir

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

Saquinavir is a selectively competitive reversible inhibitor of HIV protease. It interferes with the formation of essential proteins and enzymes, leading to the formation of immature and non-infectious viruses.
Absorption: About 30% is absorbed after oral doses. Bioavailability: About 4% when taken with food.
Distribution: 98% bound to plasma proteins. Extensively distributed into the tissues.
Metabolism: Rapidly metabolised by CYP3A4.
Excretion: Excreted mainly in the faeces. Terminal half-life: About 13.2 hr.

参考文献

1. ^ Withdrawal of Fortovase (PDF)
2. ^ Fortovase^TM (saquinavir) soft gelatin capsules. Product information (November 1997)
3. ^ Winston A, Back D, Fletcher C, et al. (2006). "Effect of omeprazole on the pharmacokinetics of saquinavir-500 mg formulation with ritonavir in healthy male and female volunteers". AIDS 20 (10): 1401–6. doi:10.1097/01.aids.0000233573.41597.8a. PMID 16791014.