AS-604850

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

AS-604850  is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 0.25, >20, >20, and 4.5 µM for the human recombinant γ, δ, β, and α isoforms, respectively. AS-604850  shows no notable activity against a wide array of protein kinases at 1 μM. AS-604850  inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg. ^[1][2]

参考文献

[1] Rameh LE et al. J Biol Chem. 1999 Mar 26;274(13):8347-50.