677338-12-4
677338-12-4
Cat.No.ABP000089
Chemical NamePIK90/PIK-90
英文名称 PIK90/PIK-90
MolFormulaC18H17N5O3
MolWeight351.3593
Purity >99%
Chemical Name : PIK90/PIK-90
CAS : 677338-12-4
英文名称: PIK90/PIK-90
英文同义词: N-(7,8-dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide
溶解度:Unknown
储存条件:at -20℃ 2 years
生物活性
PIK-90 is a potent and cell permeable PI3K inhibitor, with IC50 values (nM) of 11, 350, 18, and 58 for p110 ��, ��, �� and �� isoforms, low mTOR activity. Besides Val882 H-binding, PIK-90 uses its pyridine ring to enter the hydrophobic affinity pocket of the ATP binding site, where it also interacts with Lys833.
参考文献
[1] Marone R, Cmiljanovic V, Giese B, Wymann MP. Biochim Biophys Acta. 2008 Jan;1784(1):159-85. Epub 2007 Oct 12.
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