677338-12-4
677338-12-4
编号ABP000089
化学名称PIK90/PIK-90
英文名称 PIK90/PIK-90
分子式C18H17N5O3
分子量351.3593
纯度 >99%
化学名称 : PIK90/PIK-90
CAS : 677338-12-4
英文名称: PIK90/PIK-90
英文同义词: N-(7,8-dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide
溶解度:Unknown
储存条件:at -20℃ 2 years
生物活性
PIK-90 is a potent and cell permeable PI3K inhibitor, with IC50 values (nM) of 11, 350, 18, and 58 for p110 ��, ��, �� and �� isoforms, low mTOR activity. Besides Val882 H-binding, PIK-90 uses its pyridine ring to enter the hydrophobic affinity pocket of the ATP binding site, where it also interacts with Lys833.
参考文献
[1] Marone R, Cmiljanovic V, Giese B, Wymann MP. Biochim Biophys Acta. 2008 Jan;1784(1):159-85. Epub 2007 Oct 12.
-
D-87503/D87503
800394-83-6
-
TGX221
663619-89-4
-
PKI587/PF-05212384,PKI-587
1197160-78-3
-
R-406
841290-80-0
Copyright © 2015-2025 活性医药. All rights reserved. Support by Moldb.
浙公网安备 33010802003999号