286930-03-8

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

Urapidil α₁-adrenoceptor antagonist and 5-HT_1A receptor agonist (pIC₅₀ values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.

参考文献

Gross et al (1987) Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT_1A subtype and for a₁-adrenoceptor binding sites. Naunyn-Schmied.Arch.Pharmacol. 336 597. van Zwieten (1989) Pharmacologic profile of urapidil. Am.J.Cardiol. 64 1D. Kolassa et al (1989) Involvement of brain 5-HT_1A receptors in the hypotensive response to urapidil. Am.J.Cardiol. 64 7D.