Vandetanib intermediate 2

Reference

GW1516 (also known as GW-501, GW501516, GSK-516 or GW1516.) is a peroxisome proliferator-activated receptor agonist. And by activating PPARdelta, GW1516 increases glucose uptake in skeletal muscle, increases fat oxidation in skeletal muscle and increases muscle mass and thus also increases metabolism! Through a number of mechanisms GW1516 changes the body's metabolism into preferring burning fat for energy instead of carbohydrates and/or protein.