Delmopinol

Solubility:DMSO

Storage:at -20℃ 2 years

Biologieal

Selective RAF inhibitor, showing strong selectivity for RAF kinases among a panel of 150 tested kinases; IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.

Reference

C Montagut et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008, 68(12), 4853–4861.