2-烯丙基-1-(6-(2-羟基丙-2-基)吡啶-2-基)-6-(4-(4-甲基哌嗪-1-基)苯基氨基)-1H-吡唑并[3,4-D]嘧啶-3(2H)-酮

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2-烯丙基-1-(6-(2-羟基丙-2-基)吡啶-2-基)-6-(4-(4-甲基哌嗪-1-基)苯基氨基)-1H-吡唑并[3,4-D]嘧啶-3(2H)-酮

Cat.No.ABP000952 Chemical Name2-烯丙基-1-(6-(2-羟基丙-2-基)吡啶-2-基)-6-(4-(4-甲基哌嗪-1-基)苯基氨基)-1H-吡唑并[3,4-D]嘧啶-3(2H)-酮 CAS955365-80-7 MolFormulaC27H32N8O2 MolWeight500.5954 Purity >99%

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Chemical Name : 2-烯丙基-1-(6-(2-羟基丙-2-基)吡啶-2-基)-6-(4-(4-甲基哌嗪-1-基)苯基氨基)-1H-吡唑并[3,4-D]嘧啶-3(2H)-酮

CAS : 955365-80-7

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor with an IC50 of 0.058 ± 0.006 μM. It binds to the NH2-terminal ATP-binding pocket of Hsp90. Given the mechanism of action, preclinical activity profile, tolerability, and pharmaceutical properties, NVP-BEP800 is an exciting new oral Hsp90 inhibitor warranting further development. ^[1][2]

参考文献

[1] Massey AJ et al. Mol Cancer Ther. 2010 Apr; 9(4):906-19