PHA-793887/

溶解度:Unknown

储存条件:at -20

生物活性

PHA-793887 is a novel pan-cdk inhibitor, including cdk1, cdk2, cdk4, cdk5, cdk7, and cdk9 with IC50 in the 5 to 140 nM range. [1]It is inactive against other 34 kinases representative of all kinase families, in particular c-abl, c-kit, lck, and TRKA with IC50

参考文献

[1] Locatelli G et al. Mol Cancer Ther. 2010 May; 9(5):1265-73 [2] Alzani R et al. Exp Hematol. 2010 Apr; 38(4):259-269.e2 [3] Brasca MG et al. Bioorg Med Chem. 2010 Mar 1; 18(5):1844-53