BX795/BX-795/

Biologieal

BX 795 was initially developed as a PDK1 inhibitor. Recent study highlighted on its bioactivitiy as a potent and relatively specific inhibitor of TBK1 and closely related IKK

Reference

R I Feldman et al. Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1. J. Biol. Chem., 2005, 280, 20, 19867-19874. [online] J Bain et al. The selectivity of protein kinase inhibitors: a further update. Biochem. J. 2007, 408, 297