帕比司他

溶解度:Soluble in DMSO

储存条件:-20C 2 years

生物活性

Panobinostat (LBH589) is also a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6

参考文献

1. R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies.Arts J, Angibaud P, et al. Br J Cancer. 2007 Nov 19;97(10):1344-53. Epub 2007 Nov 13

2. Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges. Atadja P.Cancer Lett. 2009 Apr 1.