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Lappaconite Hydrobromide/


Cat.No.ABP000695 Chemical NameLappaconite Hydrobromide/ MDL: MFCD00171334 MolFormulaC32H44N2O8.BrH MolWeight665.617 Purity >99%

Chemical Name : Lappaconite Hydrobromide/

CAS : 97792-45-5


Storage:at -20℃ 2 years


Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects. Its absorption percentage in rat stomachs after administration was 9.67%.The absorption percentages at duodenum,jejunum,ileum and colon were 19.61%,11.83%,12.95% and 9.51%, respectively.When the concentration was raised from 10 mg•L-1 to 40 mg•L-1,the uptake of lappaconite hydrobromide was linearly increased,whereas the absorption rate constant kept at the same level.The inhibitors of P-glycoprotein had obvious effects on the absorption in small intestines.Sodium caprate was the best enhancer that did not cause significant changes in the morphology of the intestinal membrane after intestinal administration as compared with other absorption enhancers.


[1] Wang YZ et al. J Tradit Chin Med. 2009 Jun;29(2):141-5.