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Cat.No.ABP000084 Chemical NameXL147/XL-147 MDL: MFCD26142605 MolFormulaC21H16N6O2S2 MolWeight448.521 Purity 98%

Chemical Name : XL147/XL-147

CAS : 956958-53-5

Synonyms: N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide

Storage:at -20℃ 2 years


XL147 is a selective inhibitor of Class I PI3K isoforms. XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of PIP3 and activation of the PI3K signaling pathway.XL147 exhibits dose-dependent and sustained inhibition of PI3K signaling in multiple human tumor xenograft models when administered as a single agent. Administration of XL147 in combination with various targeted and chemotherapeutic agents results in enhanced anti-tumor activity in multiple xenograft models over that observed with the corresponding single agents.


[1] G. Shapiro et al. Meeting:2009 ASCO Annual Meeting. Citation:J Clin Oncol 27:15s, 2009 (suppl; abstr 3500)