Cat.No.ABP000272 Chemical NameAZ-23/AZ23 MDL: MFCD17215208 MolFormulaC17H19ClFN7O MolWeight391.836

Chemical Name : AZ-23/AZ23

CAS : 915720-21-7

Synonyms: AZ-23


AZ-23 represents a potent and selective Trk kinase inhibitor from a novel series with the potential for use as a treatment for cancer.AZ-23, a novel, potent, and selective Trk kinase inhibitor. In vitro studies with AZ-23 showed improved selectivity over previous compounds and inhibition of Trk kinase activity in cells at low nanomolar concentrations. AZ-23 showed in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma.


1. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway

2. Identification of 4-Aminopyrazolylpyrimidines as Potent Inhibitors of Trk Kinases

3. Pyrazolyl derivatives with analgesic activity and therefore useful in the treatment or prophylaxis of pain.