Chemical Name : ABT-888(Veliparib)/MX-1,ABT888
CAS : 912444-00-9
Solubility:Soluble in water or DMSO
Storage:-20C 2 years
BiologiealPotent inhibitor of PARP-1 and PARP-2 (potency <5nM in vitro). Does not inhibit other NAD-binding enzymes.Has minimal CYP450 inhibition and induction.Shows broad spectrum of chemo- and radiopotentiation. Enantiomeric purity >97% suitable for in vivo studies. Does not show inherent cytotoxicity and shows no single agent activity in tumor models. Has excellent bioavailability and good blood-brain permeation. Increases tumor growth delay resulting from radiation and DNA-damaging agents.
1, Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models: J.M. Albert, et al.; Clin. Cancer Res. 13, 3033 (2007) 2, ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models: C.K. Donawho, et al.; Clin. Cancer Res. 13, 2728 (2007)