912444-00-9
912444-00-9
Cat.No.ABP000419
Chemical NameABT-888(Veliparib)/MX-1,ABT888
MolFormulaC13H16N4O
MolWeight244.2923
Purity 99%
Chemical Name : ABT-888(Veliparib)/MX-1,ABT888
CAS : 912444-00-9
Synonyms: 2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide
Solubility:Soluble in water or DMSO
Storage:-20C 2 years
Biologieal
Potent inhibitor of PARP-1 and PARP-2 (potency <5nM in vitro). Does not inhibit other NAD-binding enzymes.Has minimal CYP450 inhibition and induction.Shows broad spectrum of chemo- and radiopotentiation. Enantiomeric purity >97% suitable for in vivo studies. Does not show inherent cytotoxicity and shows no single agent activity in tumor models. Has excellent bioavailability and good blood-brain permeation. Increases tumor growth delay resulting from radiation and DNA-damaging agents.Reference
1, Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models: J.M. Albert, et al.; Clin. Cancer Res. 13, 3033 (2007) 2, ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models: C.K. Donawho, et al.; Clin. Cancer Res. 13, 2728 (2007)
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NU 1025/NU1025
90417-38-2
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BSI-201/Iniparib/
160003-66-7
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AG-014699/PF-01367338，AG-14447,AG014699
459868-92-9
-
AG14361/AG-14361/
328543-09-5
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