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Cat.No.ABP000825 Chemical NameAZ-960,AZ960/ MDL: MFCD18711686 MolFormulaC18H16F2N6 MolWeight354.362 Purity >99%

Chemical Name : AZ-960,AZ960/

CAS : 905586-69-8


Solubility:Soluble in DMSO at 10 mM,


CP690550(Tasocitinib),the only Janus Kinase 3 (JAK3) inhibitor currently in clinical trials,an immunosuppressive agent exhibiting potent effects in preclinical transplantation and arthritis models; clinically safe and effective in preventing transplant rejection and improving symptoms of rheumatoid arthritis and psoriasis. CP690550(Tasocitinib) treatment of murine factor-dependent cell Patersen-erythropoietin receptor (FDCP-EpoR) cells harboring human wild-type or V617F JAK2 resulted in inhibition of cell proliferation with a IC50 of 2.1µM and 0.25 µM, respectively. Furthermore, CP690550(Tasocitinib) treatment of ex-vivo-expanded erythroid progenitors from JAK2(V617F)-positive PV patients resulted in specific, antiproliferative (IC50 = 0.2µM) and pro-apoptotic activity. In contrast, expanded progenitors from healthy controls were less sensitive to CP690550 in proliferation (IC50 > 1.0 µM), and apoptosis assays.


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2. E. Kudlacz, et al. The JAK-3 inhibitor CP690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia. Eur J Pharmacol. 2008, 582(1-3), 154-61. 3. PS Changelian et al. Prevention of Organ Allograft Rejection by a Specific Janus Kinase