Chemical Name : AZ-960，AZ960/
CAS : 905586-69-8
Solubility:Soluble in DMSO at 10 mM,
CP690550(Tasocitinib),the only Janus Kinase 3 (JAK3) inhibitor currently in clinical trials,an immunosuppressive agent exhibiting potent effects in preclinical transplantation and arthritis models; clinically safe and effective in preventing transplant rejection and improving symptoms of rheumatoid arthritis and psoriasis. CP690550(Tasocitinib) treatment of murine factor-dependent cell Patersen-erythropoietin receptor (FDCP-EpoR) cells harboring human wild-type or V617F JAK2 resulted in inhibition of cell proliferation with a IC50 of 2.1µM and 0.25 µM, respectively. Furthermore, CP690550(Tasocitinib) treatment of ex-vivo-expanded erythroid progenitors from JAK2(V617F)-positive PV patients resulted in specific, antiproliferative (IC50 = 0.2µM) and pro-apoptotic activity. In contrast, expanded progenitors from healthy controls were less sensitive to CP690550 in proliferation (IC50 > 1.0 µM), and apoptosis assays.
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