Chemical Name : TAME/
CAS : 901-47-3
Storage:at -20℃ 2 years
TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 μM. TAME binds to the APC and prevents its activation by Cdc20 and Cdh1. TAME also inhibited cyclin degradation in interphase extract activated by exogenous Cdh1, but had no effect on SCF-dependent proteolysis of β-catenin- luciferase. TAME arrested the extract in mitosis, with stable cyclin B1 and phosphorylated Cdc27. Another APC substrate, cyclinA2,was also stabilized by TAME in Xenopus extract. Besides, TAME is a potent non-airway smooth muscle constrictor with an IC50 of 43 μM in vitro. Under in vitro conditions N-alpha-tosyl L-arginine methyl ester (TAME) induced a concentration dependent contractile response on ileal strips.
 Subratty AH et al. Indian J Exp Biol. 1998 Jun;36(6):618-21.
 Subratty AH et al. Indian J Exp Biol. 1999 Apr;37(4):406-8.
 Zeng X et al. Cancer Cell. 2010 Oct 19;18(4):382-95.