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Biologieal

Leuprolide acetate is a gonadotropin-releasing hormone agonist. It acts at pituitary GnRH receptors. It down regulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to a dramatic reduction in estradiol levels. [1]

Reference

[1] http://en.wikipedia.org/wiki/Leuprorelin