718630-59-2

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PHA-793887/

718630-59-2

Cat.No.ABP000550 Chemical NamePHA-793887/ MDL: MFCD22628867 MolFormulaC19H31N5O2 MolWeight361.487 Purity >98%

Chemical Name : PHA-793887/

CAS : 718630-59-2

Synonyms: N-(6,6-DIMETHYL-5-(1-METHYLPIPERIDINE-4-CARBONYL)-2,4,5,6-TETRAHYDROPYRROLO[3,4-C]PYRAZOL-3-YL)-3-METHYLBUTANAMIDE

Storage:at -20

Biologieal

PHA-793887 is a novel pan-cdk inhibitor, including cdk1, cdk2, cdk4, cdk5, cdk7, and cdk9 with IC50 in the 5 to 140 nM range. [1]It is inactive against other 34 kinases representative of all kinase families, in particular c-abl, c-kit, lck, and TRKA with IC50

Reference

[1] Locatelli G et al. Mol Cancer Ther. 2010 May; 9(5):1265-73 [2] Alzani R et al. Exp Hematol. 2010 Apr; 38(4):259-269.e2 [3] Brasca MG et al. Bioorg Med Chem. 2010 Mar 1; 18(5):1844-53

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