71486-22-1

Storage:at -20℃ 2 years

Biologieal

Vinorelbine is the first 5´NOR semi-synthetic vinca alkaloid and an anti-mitotic chemotherapy drug. [1][2] In the breast cancer cell lines MCF-7 and MDA-MB-468, increased p38 activity was demonstrated following vinorelbine but not doxorubicin treatment, whether vinorelbine was given prior to or simultaneously with doxorubicin. Mitogen-activated protein kinase (MAPK) activity and p53 expression remained unchanged following vinorelbine treatment. [3]

Reference

[1] http://en.wikipedia.org/wiki/Vinorelbine

[2] Ngan VK et al. Cancer Res. 2000 Sep 15;60(18):5045-51