Chemical Name : AS-1413(Amonafide)/Xanafide, Quinamed
CAS : 69408-81-7
Storage:at -20℃ 2 years
AS1413 is a DNA intercalator that induces apoptotic signalling by blocking TopoII binding to DNA. Unlike classical TopoII inhibitors, a distinctive feature of AS1413 is its ability to evade PgP and related transporters responsible for multi-drug resistance. AS1413 is currently in phase III development in secondary AML.
Phase II study of amonafide in advanced and recurrent sarcoma patients Nafidamide Clinical Brochure. The National Cancer Institute, Bethesda, MD, 1984