69408-81-7

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AS-1413(Amonafide)/Xanafide, Quinamed

69408-81-7

Cat.No.ABP000387 Chemical NameAS-1413(Amonafide)/Xanafide, Quinamed MDL: MFCD00866438 MolFormulaC16H17N3O2 MolWeight283.329 Purity >99%

Chemical Name : AS-1413(Amonafide)/Xanafide, Quinamed

CAS : 69408-81-7

Synonyms: AMONAFIDE

Solubility:DMSO

Storage:at -20℃ 2 years

Biologieal

AS1413 is a DNA intercalator that induces apoptotic signalling by blocking TopoII binding to DNA. Unlike classical TopoII inhibitors, a distinctive feature of AS1413 is its ability to evade PgP and related transporters responsible for multi-drug resistance. AS1413 is currently in phase III development in secondary AML.

Reference

Phase II study of amonafide in advanced and recurrent sarcoma patients Nafidamide Clinical Brochure. The National Cancer Institute, Bethesda, MD, 1984

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