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Cat.No.ABP000098 Chemical NameTGX221 MolFormulaC21H24N4O2 MolWeight364.4409 Purity >98.5%

Chemical Name : TGX221

CAS : 663619-89-4

Synonyms: 7-Methyl-2-(morpholin-4-yl)-9-[1-(phenylamino)ethyl]pyrido[1,2-a]pyrimidin-4-one


Storage:at -20℃ 2 years


TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β .[1,2] Thrombogenix compound TGX-221 is a LY294002 analogue, able to inhibit selectively the PI3Kβ isoform in vitro. The chromone core of LY294002 was replaced with pyrido[1,2-a] pyrimidin-4-one and inserted into an aryl ring moiety, increasing the potency and selectivity against PI3Kβ(IC50=10nM).[1] 
TGX-221 is a low-nanomolar range inhibitor, shows about 1000-fold higher selectivity over PI3Kα, and is cell permeable. TGX-221 interfered with shear stress-induced PtdIns(3,4)P2 production and integrin αIIbβ3-mediated adhesion in platelets, suggesting that inhibition of PI3Kβ might have an anti-thrombotic potential in vivo.


[1] Marone R et al. Biochim Biophys Acta. 2008 Jan;1784(1):159-85