Chemical Name : VX-680 (MK-0457)
CAS : 639089-54-6
Solubility:Soluble in DMSO
Storage:-20C 2 years
VX-680 inhibits Aurorakinases A,B and C with Ki values of 0.6, 18 and 4.6 nM, resp. It also inhibits Flt-3 and Abl as well as their mutant forms
1Giles FJ, MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation.Blood. 2007 Jan 15;109(2):500-2.