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Darunavir Ethanolate(Prezista)/TMC114


Cat.No.ABP000914 Chemical NameDarunavir Ethanolate(Prezista)/TMC114 MolFormulaC29H43N3O8S MolWeight593.732 Purity >99%

Chemical Name : Darunavir Ethanolate(Prezista)/TMC114

CAS : 635728-49-3

Synonyms: [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate ethanol

Solubility:Soluble in water

Storage:-20C 2 years


Raltegravir targets integrase, an HIV enzyme that integrates the viral genetic material into human chromosomes, a critical step in the pathogenesis of HIV.


1. Potent inhibitors of HIV-1 integrase display a two-step, slow-binding inhibition mechanism which is absent in a drug-resistant T66I/M154I mutant. Garvey, E.P., Schwartz, B., et al. 2009 Biochemistry 48 (7), pp. 1644-1653