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Cat.No.ABP000086 Chemical NamePX-866/PX-866 MolFormulaC29H35NO8 MolWeight525.5901 Purity >99%

Chemical Name : PX-866/PX-866

CAS : 502632-66-8

Synonyms: (1E,4S,4aR,5R,6aS,9aR)-5-(Acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4,4a,5,6,6a,8,9,9a-octahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-cyclopenta[5,6]naphtho[1,2-c]pyran-2,7,10(1H)-trione


Storage:-20C two years


PX-866 is a biologically stable broad-spectrum PI3K inhibitor with good pharmacokinetics that causes prolonged inhibition of PI3K signaling in human tumor xenografts. PX-866 inhibited purified PI3K with an IC50 of 0.1 nmol/L and PI3K signaling measured by phospho-Ser473-Akt levels in HT-29 colon cancer cells with an IC50 of 20 nmol/L. PX-866 exhibited in vivo antitumor activity against s.c. OvCar-3 human ovarian cancer and A-549 human lung cancer xenografts in immunodeficient mice with log cell kills up to 1.2.