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Cat.No.ABP000085 Chemical NameZSTK474/ZSTK-474/ MolFormulaC19H21F2N7O2 MolWeight417.4125 Purity >98%

Chemical Name : ZSTK474/ZSTK-474/

CAS : 475110-96-4

Synonyms: 2-(difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-1H-benzimidazole

Solubility:Soluble in DMSO at 20 mg/mL; soluble in ethanol at 2.5 mg/mL with warming

Storage:Storage at -20C 2 years


ZSTK474, a novel s-triazine derivative, binds to the ATP-binding site of Class I phosphatidylinositol 3-kinases (PI3K) and inhibits PI3K activity. ZSTK474 has strong antitumor activities against human cancer xenografts (A549, PC-3 and WiDr) when administered orally to mice. Furthermore, ZSTK474 did not show significant toxicity at the doses tested.


1. Yaguchi, S., et al. "Antitumor Activity of ZSTK474, a New Phosphatidylinositol 3-Kinase Inhibitor." J. Natl. Cancer Inst. 98: 545-556 (2006).

2. Kong, D. and Yamori, T. "ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol

3 kinase isoforms." Cancer Sci. 98: 1638-1642 (2007). 3. ZSTK474 is a far more potent Class I PI3K inhibitor than LY294002, by a factor of 30-fold or more, and it is far more stable than wortmannin. Kong, D. and Yamori, T., ibid.