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LBH-589/Panobinostat /LBH589


Cat.No.ABP000143 Chemical NameLBH-589/Panobinostat /LBH589 MDL: MFCD09833242 MolFormulaC21H23N3O2 MolWeight349.432 Purity 99%

Chemical Name : LBH-589/Panobinostat /LBH589

CAS : 404950-80-7

Synonyms: N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide;PANOBINOSTAT

Solubility:Soluble in DMSO

Storage:-20C 2 years


Panobinostat (LBH589) is also a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6


1. R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies.Arts J, Angibaud P, et al. Br J Cancer. 2007 Nov 19;97(10):1344-53. Epub 2007 Nov 13

2. Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges. Atadja P.Cancer Lett. 2009 Apr 1.