Chemical Name : LBH-589/Panobinostat /LBH589
CAS : 404950-80-7
Solubility:Soluble in DMSO
Storage:-20C 2 years
Panobinostat (LBH589) is also a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6
1. R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies.Arts J, Angibaud P, et al. Br J Cancer. 2007 Nov 19;97(10):1344-53. Epub 2007 Nov 13
2. Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges. Atadja P.Cancer Lett. 2009 Apr 1.