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Cat.No.ABP000092 Chemical NameIC-87114 MDL: MFCD09970845 MolFormulaC22H19N7O MolWeight397.44 Purity >98%

Chemical Name : IC-87114

CAS : 371242-69-2

Synonyms: 2-[(6-Amino-9h-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H-quinazolinone


A small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. PI3K-delta inhibitor CAL-101 inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.


1.Dose Escalation Study of CAL-101 in Select Relapsed or Refractory Hematologic Malignancies 2.Study to Investigate CAL-101 in Combination With Bendamustine and Rituximab in Patients With Relapsed or Refractory Indolent B-cell Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia