364782-34-3

Solubility:DMSO

Storage:at -20℃ 2 years

Biologieal

AMG-073(Cinacalcet hydrochloride) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium. The current study evaluates the efficacy and safety of AMG 073 when added to conventional treatment of secondary hyperparathyroidism in end-stage renal disease (ESRD).

Reference

[1] Quarles LD et al. J Am Soc Nephrol. 2003 Mar;14(3):575-83.