356559-20-1
356559-20-1
Cat.No.ABP000161
Chemical NameSB 525334/SB525334
MolFormulaC21H21N5
MolWeight343.4249
Purity >98%
Chemical Name : SB 525334/SB525334
CAS : 356559-20-1
Synonyms: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
Solubility:DMSO
Storage:at -20°
Biologieal
SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50=14.3 nM). This agent inhibits TGF-β-induced ALK5 serine/ threonine kinase activity, thereby preventing phosphorylation of the Smad transcription factors and subsequent gene activation.Reference
[1] Laping NJ. IDrugs 1999;2:907-14
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