Cat.No.ABP000232 Chemical NameSB-431542 MolFormulaC22H16N4O3 MolWeight384.3874 Purity >99 %

Chemical Name : SB-431542

CAS : 301836-41-9

Synonyms: 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide

Solubility:Soluble to 10 mM in Ethanol and to 100 mM in DMSO

Storage:-20C 2 years


Potent and selective inhibitor of the transforming growth factor-ß (TGF-ß) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-ß-induced proliferation of human osteosarcoma cells.


1. Laping et al (2002) Inhibition of transforming growth factor (TGF)-b1-induced extracellular matrix with a novel inhibitor of the TGF-b type I receptor kinase activity: SB-431542. Mol.Pharmacol. 62 58.

2. Inman et al (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-b superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol.Pharmacol. 62 65.