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Cat.No.ABP000463 Chemical NameRS-504393 MolFormulaC25H27N3O3 MolWeight417.5002 Purity 98%

Chemical Name : RS-504393

CAS : 300816-15-3

Synonyms: 6-Methyl-1'-[2-(5-methyl-2-phenyl-4- oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piper idin]-2(1H)-one

Solubility:#000000">Solubility: Soluble to 10 mM in DMSO

Storage:Store at -20°C


Extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.


Mirzadegan et al (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists. J.Biol.Chem. 275 25562. Furuichi et al (2003) CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J.Am.Soc.Nephrol. 14 2503. Kitagawa et al (2004) Blockade of CCR2 ameliorates progressive fibrosis in kidney. Am.J.Pathol. 165 237.