Chemical Name : SB 216763/SB-216763
CAS : 280744-09-4
Synonyms: 3-(2,4-Dichlorophenyl)-4-(1-methyl- 1H-indol-3-yl)-1H-pyrrole-2,5-dione
Solubility:20 mg/mL in DMSO
Storage:Storage at -20C 2 years
BiologiealPotent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective. Also reduces pulmonary inflammation and fibrosis in a mouse model.