280744-09-4

SB 216763/SB-216763

280744-09-4

Cat.No.ABP000231 Chemical NameSB 216763/SB-216763 MolFormulaC19H12Cl2N2O2 MolWeight371.217 Purity >99%

Chemical Name : SB 216763/SB-216763

CAS : 280744-09-4

Synonyms: 3-(2,4-Dichlorophenyl)-4-(1-methyl- 1H-indol-3-yl)-1H-pyrrole-2,5-dione

Solubility:20 mg/mL in DMSO

Storage:Storage at -20C 2 years

Biologieal

Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective. Also reduces pulmonary inflammation and fibrosis in a mouse model.
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