Home / Products / Inhibitors / EGFR inhibitor / 231277-92-2


Cat.No.ABP000872 Chemical NameLapatinib MolFormulaC29H26ClFN4O4S MolWeight581.058 Purity 99%

Chemical Name : Lapatinib

CAS : 231277-92-2

Synonyms: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine

Storage:at -20℃ 2 years





Neratinib is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively.[1] Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.[2]


[1] Tsou HR et al. J Med Chem. 2005 Feb 24;48(4):1107-31.