Chemical Name : Bortezomib/Velcade, MG-341, PS-341
CAS : 179324-69-7
Synonyms: [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
Solubility:Soluble in DMSO at 200mg/mL, ethanol at 200mg/mL
Storage:-20C 2 years
Bortezomib blocks TNF-induced NF-kB activation in a dose- and time-dependent fashion in multiplemyeloma cells through degradation of IkB. Bortezomib caused comparable growth suppression in LNCaP-Pro5 and PC3M-Pro4 cells with an IC90 of 10 nM. Bortezomib inhibits cell proliferation of H460 cells (Human non-small cell lung cancer cell lines) with an IC50 of 0.1 µM. In a study with the National Cancer Institute's panel of 60 human cell lines, bortezomib showed a mean IC50 of 7 nM as tested by SRB analysis.
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