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Vorinostat (SAHA)/Zolinza, MK-0683


Cat.No.ABP000147 Chemical NameVorinostat (SAHA)/Zolinza, MK-0683 MDL: MFCD00945317 MolFormulaC14H20N2O3 MolWeight264.323 Purity 99%

Chemical Name : Vorinostat (SAHA)/Zolinza, MK-0683

CAS : 149647-78-9


Solubility:Soluble in Ethanol or DMSO

Storage:-20C 2 years


Suberoylanilide hydroxamic acid (SAHA). Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. Vorinostat efficiently suppressed MES-SA cell growth at a low dosage (3 μM) already after 24 hours treatment. Decrease of cell survival was even more pronounced after prolonged treatment and reached 9% and 2% after 48 and 72 hours of treatment, respectively. Colony forming capability of MES-SA cells treated with 3 μM vorinostat for 24 and 48 hours was significantly diminished and blocked after 72 hours. [2]


[1] Takashi Kumagai et al. International Journal of Cancer.2007,121(3):656-665

[2] Hrzenjak A et al. Mol Cancer. 2010 Mar 4;9:49