Chemical Name : Y-27632 dihydrochloride
CAS : 146986-50-7
Synonyms: (1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride;4-[(1R)-1-AMINOETHYL]-N-(4-PYRIDYL)CYCLOHEXANE-1-CARBOXAMIDE DIHYDROCHLORIDE
Solubility:Soluble to 100mM in Phosphate buffered saline and to 100mM in Water
Storage:-20C 2 years
Selective inhibitor of the Rho-associated protein kinase p160ROCK. Ki values are 0.14, 26, 25 and >250 µM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2. Smooth muscle relaxant and orally active in vivo.
1Uehata et al (1997) Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase. Nature 389 990. 2��Itoh et al (1998) An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nature Med. 5 221. 3Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95. 4��Narumiya et al (2000) Use and properties of ROCK-specific inhibitor Y-27632. Methods Enzymol. 325 273.